PGS Malaysia

31/03/2023

Why Assessing Genetic Normality Of IVF Embryos By AI Is A Better Option

It might be preferable for older women undergoing IVF to screen their embryos for genetic abnormalities, before transferring them into their wombs.

31/03/2023

Clinical trial shows that PGS / PGT-A reduces live birth rates in IVF

Following neutral results in several high profile RCTs, PGT-A has once again failed to demonstrate its benefit in terms of LBR, now in a new cohort analysis from the SART database. Can the results be explained by mosaicism in some embryos, misdiagnosis, or biopsy?

21/03/2023

Prominent Doctors and Scientists Criticize Continued Utilization of Preimplantation Genetic Testing for Aneuploidy (PGT-A) in IVF and Warn about a New Fourth Generation Test

January 12, 2021 -- While biological ability of human embryos to self-correct genetic abnormalities renders PGT-A fundamentally useless, more and more IVF centers push the costly test on already cost-burdened fertility patients

21/03/2023

New research casts fresh doubt on a common procedure that promises to increase the odds of IVF

New research casts further doubt on a common — and controversial —procedure that promises to increase the odds of IVF.

14/03/2023

Malaysia needs stricter regulation of the genetic testing of embryos

Photo: EVGENIY SALOV/Dreamstime/Tribune News Service DOWN syndrome is the most common genetic abnormality in newborns, and it is caused by the presence of an additional chromosome 21. As World Down Syndrome day approaches on March 21, we are reminded of the sobering statistic that around 90% of Down...

12/07/2022

Why Assessing Genetic Normality Of IVF Embryos By AI Is A Better Option https://codeblue.galencentre.org/2022/07/08/why-assessing-genetic-normality-of-ivf-embryos-by-ai-is-a-better-option-dr-alexis-heng-boon-chin/

It might be preferable for older women undergoing IVF to screen their embryos for genetic abnormalities, before transferring them into their wombs.

05/07/2022

Genetic testing controversy clouds medical tourism in Malaysia https://www.ucanews.com/news/genetic-testing-controversy-clouds-medical-tourism-in-malaysia/97887

Wealthy couples from Singapore and China are flocking to Malaysia for IVF genetic testing

19/11/2021

Cost-effectiveness of doing genetic testing of IVF embryos ( PGS / PGT-A ) to prevent Down syndrome and other genetic abnormalities in older mothers
https://thenewsavvy.com/life-changes/children/cost-effectiveness-of-doing-genetic-testing-of-ivf-embryos-pgs-pgt-a-to-prevent-down-syndrome-and-other-genetic-abnormalities-in-older-mothers/

Currently, there is an increasing trend of late motherhood in Singapore and many other countries throughout the world, as rising numbers of better-educated women choose to postpone marriage and childbearing in pursuit of career development. Nevertheless, there are heightened risks of conceiving a ba...

14/10/2021

Genetic Testing Of IVF Embryos Overseas: What Singaporean Patients Should Know https://sg.style.yahoo.com/genetic-testing-ivf-embryos-overseas-053018918.html

Singaporean patients traveling abroad for IVF treatment should be cautious not to be ‘pushed’ into undertaking PGS unnecessarily. The post Genetic Testing Of IVF Embryos Overseas: What Singaporean Patients Should Know appeared first on theAsianparent - Your Guide to Pregnancy, Baby & Raising Kid...

14/10/2021

IVF genetic testing to prevent birth defects in older women https://www.biospectrumasia.com/opinion/54/19177/ivf-genetic-testing-to-prevent-birth-defects-in-older-women.html?fbclid=IwAR13Ka9CszB9YHWFMZMav-W_EJJcTpoY-CrwTTDcmBy7upyNmpbsBRvXBKU

In conversation with Dr. Alexis Heng Boon Chin, Associate Professor, Peking University, China

19/02/2021

Abnormal embryos diagnosed by PGS / PGT-A can give rise to normal healthy births. PGS maybe unnecessary and a waste of money!

Please take note of the controversy surrounding PGS with regards to Mosaic embryos, which have a mixture of normal (euploid) and abnormal (aneuploid) cells. These are often tested to be genetically abnormal by PGS, but in fact can give rise to normal healthy births.
As seen in the attached diagram of a blastocyst-stage human embryo, the ICM gives rise to the embryo, while the TE gives rise to the placenta and yolk sac. Testing a few cells from the TE only gives you a probability about what's going on in the ICM. An embryo with abnormal (aneuploid) TE but normal ICM most likely will still make a healthy baby.
Hence, by discarding such mosaic embryos that are tested abnormal during PGS, one would lower the cumulative chances of IVF success.

19/02/2021

New scientific evidence dispute the beneficial effects of PGS / PGT-A in IVF Treatment

https://singaporemotherhood.com/forum/threads/new-scientific-evidence-dispute-the-beneficial-effects-of-pgs-pgt-a-in-ivf-treatment.259583/

Many fertility clinic websites claim that PGS can improve IVF success for older women and patients with multiple IVF failures or recurrent miscarriages. However, there has recently been increasing contradictory information from different sources, which dispute the beneficial claims of PGS in IVF...

19/02/2021

Is PGS (PGT-A) useful for older women at risk of Down Syndrome, or patients with low ovarian reserves?

https://singaporemotherhood.com/forum/threads/is-pgs-pgt-a-useful-for-older-women-at-risk-of-down-syndrome-or-patients-with-low-ovarian-reserves.257325/

Relevant Q & A on the Quora website: https://www.quora.com/Why-may-it-be-unnecessary-for-older-women-undergoing-IVF-or-ICSI-to-do-pre-implantation-genetic-screening-PGS-PGT-A/answer/Alexis-Heng https://www.quora.com/How-can-I-do-preimplantation-genetic-screening-PGS-or-PGT-A-in-Singapore-1...

19/02/2021

Video podcasts that explain the Preimplantation Genetic Screening (PGS or PGT-A) procedure. What are the limitations and risks of PGS / PGT-A?

https://singaporemotherhood.com/forum/threads/video-podcasts-that-explain-the-preimplantation-genetic-screening-pgs-or-pgt-a-procedure-what-are-the-limitations-and-risks-of-pgs-pgt-a.259185/

Here are some excellent video podcasts that introduce and explain the Preimplantation Genetic Screening (PGS or PGT-A) procedure to patients:

19/02/2021

What Singaporean patients should know before doing PGS (embryo genetic testing) when going for IVF overseas

https://singaporemotherhood.com/forum/threads/what-singaporean-patients-should-know-before-doing-pgs-embryo-genetic-testing-when-going-for-ivf-overseas.258839/

There are plenty of arguments against doing preimplantation genetic screening - PGS / PGT-A, and it’s up to you to decide if they outweigh the pros… https://theduff.co.uk/pgs-testing-ivf/ Argument 1 against PGS: it’s expensive Paying an extra $5,000 (ish) per cycle – on top of the $10,000 or...

19/02/2021

Here are the latest news on Preimplantation Genetic Screening (PGS / PGT-A), which cast doubts on the usefulness and effectiveness of this technique for older women undergoing IVF / ICSI :

https://singaporemotherhood.com/forum/threads/latest-news-on-pgs-pgt-a-embryo-genetic-testing-which-cast-doubts-on-the-usefulness-and-effectiveness-of-this-technique-for-older-women.261916/

Here are the latest news on Preimplantation Genetic Screening (PGS / PGT-A), which cast doubts on the usefulness and effectiveness of this technique for older women undergoing IVF / ICSI : Prominent Physicians and Scientists Criticize Continued Utilization of Preimplantation Genetic Testing for...

19/02/2021

Controversial and unethical use of PGS / PGT-A for s*x selection overseas by Singapore patients

https://singaporemotherhood.com/forum/threads/controversial-and-unethical-use-of-pgs-pgt-a-for-s*x-selection-overseas-by-singapore-patients.257958/

Several years ago, the Straits Times reported on Singaporean couples traveling overseas for embryo s*x selection by preimplantation genetic screening (PGS) via IVF treatment, due to the procedure being banned here. It was reported that most Singaporean Chinese couples doing PGS preferred a son...

19/02/2021

Images related to mosaic IVF embryos and risks of misdiagnosis by PGS / PGT-A