09/16/2024
Our "in-vivo like" Blood-Brain Barrier (BBB) is being used to study the link between Periodontitis (PD) and Alzheimer's Disease (AD).
With the help of our model, the scientists found that not only do PD-induced exosomes cross the BBB, but they also compromise its integrity. TEER readings and expression of tight-junction proteins both decrease after exposure to the exosomes. These findings give some insight into how PD may contribute to the development of AD.
Image: TEER readings in Neuromics BBB model at different time points when blood side is exposed to PD exosomes (PD EXO) and health exosomes (Con EXO). Exposure to PD EXO decreases TEER readings.
Check our BBB Model-https://www.neuromics.com/3D45002. David Rupp Kathleen Stark Neuroscience News and Research Society for Neuroscience