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Journal of General Physiology

Name: Journal of General Physiology
Address: 950 3rd Avenue, Fl 2nd, New York, NY, 10022, US
Telephone: +12123277938
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Journal of General Physiology

The Journal of General Physiology publishes research in physiological problems at cellular and molecular level. Published by Rockefeller University Press.

The Journal of General Physiology publishes peer-reviewed research in biological, chemical, or physical mechanisms of broad physiological significance, with an emphasis on physiological problems at the cellular and molecular level. Areas include, but are not limited to:

- Membrane protein physiology
- Protein structure and dynamics
- Lipid and membrane biophysics
- Cell mechanics
- Intracellular

and intercellular signaling

All editorial decisions are made by research-active scientists in conjunction with in-house scientific editors. JGP provides free online access to many article types from the date of publication and to all archival content. Established in 1918, JGP is published by The Rockefeller University Press. For more information, visit http://jgp.rupress.org. Follow us on Twitter: https://twitter.com/JGenPhysiol

09/20/2024

Saffie Mohran, Weikang Ma and colleagues (Illinois Institute of Technology / University of Washington) show that calcium has a direct effect on thick filament activation in myocardium rather than an indirect effect due to calcium-mediated crosstalk between the thick and thin filaments. Their findings should be considered in developing future drug candidates to treat heart diseases. https://hubs.la/Q02QBWNG0

09/20/2024

Lina Kraujaliene, Vytas Verselis and colleagues (Albert Einstein College of Medicine) use modeling and dye uptake/transfer studies to show that an Ala/Glu difference in the E1 domains of Cx26 and Cx30 can account for their differential permeabilities to anionic permeants. The permeability profiles are conserved in gap junction channels and hemichannel configurations. https://hubs.la/Q02QBLNH0

09/20/2024

Two connexins, Cx26 and Cx30, are expressed in the cochlea and play vital roles in hearing. Helmuth Sanchez, Lina Kraujaliene, and Vytas Verselis (Albert Einstein College of Medicine) identified a sequence difference in their E1 domains that differentially affects their abilities to operate as hemichannnels and function in transmembrane signaling. https://hubs.la/Q02QBPMt0

09/18/2024

📣 Deadline October 1st ⚠️ We welcome papers on the topic of the 2024 Myofilament Meeting: “Contractile Systems, Mechanobiology and Regulation: Novel Concepts, Technologies and Applications.” Learn more and submit your research ➡️ https://hubs.la/Q02Q72bp0

09/17/2024

This tutorial from Eduardo Ríos (Rush University) provides the ideas and information needed to understand, at a basic level, the application of convolutional neural networks to analyze images in biology and traces a path to adopting the available applications of machine learning to biology research. https://hubs.la/Q02Q6ZWs0

09/04/2024

Using a mathematical model, D. George Stephenson (La Trobe University) tests the hypothesis that the characteristic response to Ca2+ of RyR channels is key not only for the Ca2+ release mechanism in cardiac muscle and other tissues, but also for the DHPR-dependent Ca2+ release in skeletal muscles. https://hubs.la/Q02NJ4Bw0

09/03/2024

JGP is pleased to present a special collection of articles to accompany the 77th Annual Meeting of the Society of General Physiologists, “Molecular Evolution in the Membrane: Ion Channels, Transporters, and Receptors.” 👉 https://hubs.la/Q02N9bPM0

The selected articles explore a diverse range of topics, from the transport of metformin metabolites by small multidrug resistance proteins in bacteria to the distinct functional properties and pharmacology of honeybee voltage-gated calcium channels. Additional topics include the optimization of CFTR gating through its extracellular loop, the regulation of ion channel activation and inactivation and how mutations linked to epilepsy and channelopathies alter ion channel function. 👉 https://hubs.la/Q02N9bPM0

09/02/2024

Our September issue is out! https://hubs.la/Q02N4zxp0
🔬 The cover shows how two AI modules extract from a skeletal muscle EM image the pixel-wise fraction (pf) of glycogen granules. A numerical simulation derives from pf the voxel-wise fraction (vf) proportional to glycogen concentration, which decreases approximately threefold in patients susceptible to malignant hyperthermia.
Eduardo Ríos et al. (https://hubs.la/Q02N4zKC0) propose artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue.

08/22/2024

New commentary: Rad is an emerging key Cav1.2 modulator. In a new study, Elmore, Ahern et al. (https://hubs.la/Q02MbNRN0) examine how the Rad C-terminus affects its subcellular distribution and Cav1.2 regulation. Commentary from Cherrie Kong and Eef Dries (KU Leuven): https://hubs.la/Q02MbPW70

08/20/2024

Taylor Mott, Eric Senning (The University of Texas at Austin) and colleagues evaluate two click-chemistry protein labeling tools based on genetic code expansion technology and circularly permutated Halotag, respectively, for their utility in TRPV1 cell surface expression studies. https://hubs.la/Q02LVYZR0

08/20/2024

📣 Call for Papers 📣 Deadline extended to 10/15/2024! You are invited to submit papers on Voltage-Gated Sodium Channels to be published throughout the year and highlighted in a special issue 📙 ➡️ https://hubs.la/Q02LVj1Y0

JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. Topics of interest include but are not limited to, atomistic modelling, biophysics of gating, structural and biochemical investigations, computer simulations, cellular excitability, subcellular expression and regulation, sodium channels in diseases (cardiac, muscle, pain, epilepsy and any other) and mechanistic investigations of sodium channelopathies using new model systems, such as stem cell-derived cells. We also welcome studies involving patients suffering from sodium channel-related diseases.

Submit your research here ➡️ https://hubs.la/Q02LVj1Y0

08/13/2024

New Commentary: Danuta Szczesna-Cordary (University of Miami Miller School of Medicine) discuss new study from Kooiker et al. (https://hubs.la/Q02L6_Fb0) showing that the new RLC-1 small-molecule inhibits actomyosin interactions, reduces contractile force, and speeds up myosin cross-bridge kinetics: https://hubs.la/Q02L71ck0

08/07/2024

Man Si, Edward Glasscock et al. (SMU) (https://hubs.la/Q02KqCRH0) reveal that, although they are present at low levels and only generate small currents in the sinoatrial node, Kv1.1 channels have a significant impact on cardiac pacemaking. Learn more in our latest Research News: https://hubs.la/Q02KqDls0

08/05/2024

Our August issue is now available online: https://hubs.la/Q02JTCH_0. The cover represents voltage-dependent activation of spHCN channels tracked in realtime using fluorophores covalently linked to a Cys in the S4 helix to reveal different components of S4 movement. Structural modeling suggests that the distinct fluorescence responses result from different constraints on the fluorophore orientation in the resting and activated states. Image from Wojciechowski et al., 2024. (https://hubs.la/Q02JTJ_00)

07/31/2024

Kristina Kooiker et al. (University of Washington) investigate the mechanisms of a novel cardiac myosin inhibitor that depends on the presence of a myosin regulatory light chain (RLC-1). They show that RLC-1 destabilizes myosin interactions to inhibit force and accelerate kinetics in cardiac muscle. https://hubs.la/Q02Jy_fQ0

07/25/2024

New Review: Cheyanne Lewis and Theanne Griffith (UC Davis) discuss developments in ion channels of cold transduction and transmission. https://hubs.la/Q02HYnnW0

07/23/2024

The ω-Grammotoxin-SIA peptide (GrTx-SIA) was originally found in tarantula venom and shown to inhibit voltage-gated Ca2⁺ channels. Here, Rita de Cássia Collaço, Filip Van Petegem, and Frank Bosmans (Universiteit Gent) report that GrTx-SIA can also potently inhibit voltage-gated Na⁺ channel currents with Naᵥ1.6 being the most susceptible subtype. https://hubs.la/Q02HDrpq0

07/22/2024

Man Si, Edward Glasscock (SMU) and colleagues use electrophysiology to show that genetic or pharmacological ablation of Kv1.1 K+ channel subunits reduces the firing rate of the heart’s sinoatrial node in mice. They attribute this decrease to impaired outward K+ currents resulting in prolonged action potentials. These findings identify Kv1.1 as a novel regulator of cardiac pacemaking. https://hubs.la/Q02HrFC60

07/15/2024

New: Zahra Aminzare and Alan Kay (University of Iowa) calculate how cells prevent themselves from bursting. They upgraded pump-leak equations that are used to characterize cell volume regulation to include more cell parts and energy details. https://hubs.la/Q02GyDSV0

07/12/2024

RRAD is a constituent of the L-type calcium channel heteromultimeric complex. RRAD contributes to calcium channel modulation. Garrett Elmore, Brooke Ahern, Bryana Levitan, Jonathan Satin & colleagues (University of Kentucky) show that the RRAD C-terminus confers membrane association concomitantly with the regulation of ICa,L modulation and in vivo heart function. https://hubs.la/Q02Gm4l60

07/10/2024

New commentary: Joachim Nielsen (Syddansk Universitet – University of Southern Denmark) discusses the implications of a new study from Ríos et al. (https://hubs.ly/Q02G10NK0) demonstrating an model to quantify glycogen granules. https://hubs.ly/Q02G10h00

07/10/2024

New study from Eduardo Ríos (Rush University) and colleagues uses AI to analyze muscle images, finding granular content that varies w/ cell region and is threefold lower than normal in patients susceptible to malignant hyperthermia. https://hubs.ly/Q02G10ph0

07/09/2024

Magdalena Wojciechowski, Christopher Reid, Ian Forster and colleagues (The Florey Institute of Neuroscience and Mental Health) used voltage clamp fluorometry to probe the S4 helix movement in the voltage-sensing domain of the sea urchin HCN channel expressed in Xenopus oocytes. They found that when labeled with either ALEXA-488 or MTS-TAMRA, each fluorophore reported different components of S4 movement. https://hubs.la/Q02FPk7B0

07/01/2024

Our July issue is out! https://hubs.la/Q02DjlY80
The cover shows how niclosamide, an anthelmintic medication, binds to a putative extracellular binding site on the TMEM16A calcium-activated chloride channel, enhancing its activation under physiological conditions.
Liang et al. (https://hubs.la/Q02Djg0K0) reveal that niclosamide, a proposed TMEM16A inhibitor for asthma and COPD, unexpectedly enhances TMEM16A activity, raising caution for its clinical use. They also discover its binding site on TMEM16A, aiding in developing targeted modulators for various diseases.

06/26/2024

📣 Call for Papers 👉 https://hubs.la/Q02DjcwP0
JGP invites you to submit papers on the topic of the 2024 Myofilament Meeting (https://hubs.la/Q02Djj330): “Contractile Systems, Mechanobiology and Regulation: Novel Concepts, Technologies and Applications,” to be published throughout the year and highlighted in a special issue!

Guest editors of the special issue are Elisabetta Brunello of King’s College London, Aikaterini Kontrogianni-Konstantopoulos of the University of Maryland, Kerry McDonald of the University of Missouri, and Michael Regnier of the University of Washington.

The deadline for submission for inclusion in the special issue is October 1, 2024! 👉 https://hubs.la/Q02DjcwP0

06/20/2024

📣Call for Papers!📣 JGP invites you to submit papers on the topic of the Society of General Physiologists’ 77th Annual Symposium: “Molecular Evolution in the Membrane: Ion Channels, Transporters, and Receptors” to be published throughout the year and highlighted in a special issue. 👉 https://hubs.la/Q02BzXNT0
We welcome submissions that provide new insights on ion channels, transporters, receptors, and membrane enzymes. Guest editors are Lucy Forrest of the National Institutes of Health and Randy Stockbridge of the University of Michigan, assisted by JGP Associate Editors Chris Lingle of Washington University School of Medicine in St. Louis and Crina Nimigean of Weill Cornell Medicine. Learn more 👉 https://hubs.la/Q02BzXNT0

06/12/2024

📣 Call for Papers 📣
You are invited to submit papers on Voltage-Gated Sodium Channels to be published throughout the year and highlighted in a special issue! ➡️ https://hubs.la/Q02BxM3K0

This special issue was initiated in the context of the Worldwide Sodium Channel Conference in Grindelwald, Switzerland, January 31 to February 2, 2024.

Guest editors are Angelika Lampert of the RWTH Aachen University, Germany, and Hugues Abriel of the University of Bern, Switzerland. They are assisted in handling the submitted manuscript reviews by JGP Editor-in-Chief David Eisner of Manchester University and JGP Associate Editor Jeanne Nerbonne of Washington University School of Medicine in St. Louis.

JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. Topics of interest include but are not limited to, atomistic modelling, biophysics of gating, structural and biochemical investigations, computer simulations, cellular excitability, subcellular expression and regulation, sodium channels in diseases (cardiac, muscle, pain, epilepsy and any other) and mechanistic investigations of sodium channelopathies using new model systems, such as stem cell-derived cells. We also welcome studies involving patients suffering from sodium channel-related diseases. ➡️ https://hubs.la/Q02BxM3K0

06/11/2024

In a new study, Vamseedhar, Kohout and colleagues (https://hubs.la/Q02Bnq1Y0) show that hydrophobic residues in the S1 transmembrane domain modulate the voltage-sensor movements and enzymatic activity of voltage-sensing phosphatase. Highlighted in our latest : https://hubs.la/Q02Bnpy50

06/11/2024

The impact of fusion pores on synaptic release is difficult to discern. Through analysis of miniature excitatory synaptic currents, Meyer Jackson, Chung-Wei Chiang, and Jinbo Cheng (University of Wisconsin-Madison) reveal a correlation between amplitude and rise-time. Modeling indicates this correlation results from the interplay between vesicle size and fusion pore flux. https://hubs.la/Q02BnyLg0

06/05/2024

ON and OFF signals in the retina are processed via parallel pathways. Mie Gangi and colleagues (Nippon Medical School) reveal that regulation of starburst amacrine cells, which are crucial for motion detection, is different between the ON and OFF pathways, despite their morphological mirror symmetry. https://hubs.la/Q02zFsKP0

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Videos

Pengfei Liang, Huanghe Yang (Duke University School of Medicine) and colleagues reveal that niclosamide, a proposed TMEM16A inhibitor for asthma and COPD, unexpectedly enhances TMEM16A activity, raising caution for its

Pengfei Liang, Huanghe Yang (Duke University School of Medicine) and colleagues reveal that niclosamide, a proposed TMEM16A inhibitor for asthma and COPD, unexpectedly enhances TMEM16A activity, raising caution for its clinical use. They also discover its binding site on TMEM16A, aiding in developing targeted modulators for various diseases. https://hubs.la/Q02yZGmj0

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Today on #InternationalWomensDay we celebrate women scientists #WomenInSTEM who continue to #BreakTheBias! Happy #IWD2022 #WHM2022 https://www.internationalwomensday.com