Journal of General Physiology

Journal of General Physiology The Journal of General Physiology publishes research in physiological problems at cellular and molecular level. Published by Rockefeller University Press.

The Journal of General Physiology publishes peer-reviewed research in biological, chemical, or physical mechanisms of broad physiological significance, with an emphasis on physiological problems at the cellular and molecular level. Areas include, but are not limited to:

- Membrane protein physiology
- Protein structure and dynamics
- Lipid and membrane biophysics
- Cell mechanics
- Intracellular

and intercellular signaling

All editorial decisions are made by research-active scientists in conjunction with in-house scientific editors. JGP provides free online access to many article types from the date of publication and to all archival content. Established in 1918, JGP is published by The Rockefeller University Press. For more information, visit http://jgp.rupress.org. Follow us on Twitter: https://twitter.com/JGenPhysiol

New work from Seong Won Han et al. (https://hubs.la/Q03sDXnq0) reveals that glycerol storage increases the titin-based s...
06/18/2025

New work from Seong Won Han et al. (https://hubs.la/Q03sDXnq0) reveals that glycerol storage increases the titin-based stiffness of muscle fibers, suggesting this commonly used method should be avoided by researchers interested in the passive properties of muscle. https://hubs.la/Q03sDXjN0

Danicamtiv & omecamtiv mecarbil are second- and first-generation myotropic sarcomere activators intended to treat patien...
06/18/2025

Danicamtiv & omecamtiv mecarbil are second- and first-generation myotropic sarcomere activators intended to treat patients w/ with reduced ejection fraction. New work by Holmes & Stelzer directly compares the drugs' in vivo cardiac mechanisms https://hubs.la/Q03sDZ6p0

David Gong, Charles Abrams and colleagues (University of Illinois Chicago) present two novel, disease-causing genetic va...
06/10/2025

David Gong, Charles Abrams and colleagues (University of Illinois Chicago) present two novel, disease-causing genetic variants of 47. In vitro assays and MD simulations of these mutant proteins reveal unique mechanisms that relate connexin 47 mutations to severities of Pelizaeus–Merzbacher-like disease 1. https://hubs.la/Q03rtJtJ0

Metaphors shape how we communicate & understand science, from genetic blueprints to molecular gates. Peter Hull and Ange...
06/03/2025

Metaphors shape how we communicate & understand science, from genetic blueprints to molecular gates. Peter Hull and Angelica Lampert (Uniklinik RWTH Aachen) explore their role in the sodium channel fast inactivation mechanism-accessible to readers without a linguistics background. https://hubs.la/Q03qrtr10

“By identifying and promoting good science, treating authors with decency and respect, and ensuring quality of peer revi...
05/21/2025

“By identifying and promoting good science, treating authors with decency and respect, and ensuring quality of peer review, among many other activities, editors nurture the reputation and quality of journals.” Read the editorial by our sister journal LSA’s new Executive Editor Tim Fessenden: https://hubs.la/Q03nyYWG0

Josè Manuel Pioner, Enrico Pierantozzi, Cecilia Ferrantini, Vincenzo Sorrentino et al. show that obscurin deletion in mi...
05/14/2025

Josè Manuel Pioner, Enrico Pierantozzi, Cecilia Ferrantini, Vincenzo Sorrentino et al. show that obscurin deletion in mice is linked to compensated dilated cardiomyopathy, reduced sarcoplasmic reticulum volume, T-tubule alterations, altered E-C coupling, impaired response to inotropic agents, and increased propensity to arrhythmias. https://hubs.la/Q03mtC0k0

To store and preserve muscle function, glycerol is often used, but its effect on passive properties is unclear. Seong-Wo...
05/09/2025

To store and preserve muscle function, glycerol is often used, but its effect on passive properties is unclear. Seong-Won Han, Henk Granzier and colleagues (The University of Arizona) show that muscles stored in glycerol showed increased passive stress that persisted after thin filament removal, indicating a titin-specific mechanism. Glycerol storage should be avoided in passive stiffness studies. https://hubs.la/Q03lRxkS0

FGF14 encodes a sodium channel accessory subunit. Mutations in Fgf14 are linked to spinocerebellar ataxia type 27. Fgf14...
05/05/2025

FGF14 encodes a sodium channel accessory subunit. Mutations in Fgf14 are linked to spinocerebellar ataxia type 27. Fgf14 deletion in mouse Purkinje neurons causes reduced excitability. Joseph Ransdell, Jeanne Nerbonne and colleagues (WashU Medicine) show that targeted Fgf14 deletion in mouse CA1 pyramidal neurons causes increased firing, revealing cell-type specific effects. https://hubs.la/Q03l3j8z0

Our May issue is here! https://hubs.la/Q03kt3v40The cover shows Comb Jelly (Mnemiopsis gardeni, Flagler Beach, FL) with ...
05/05/2025

Our May issue is here! https://hubs.la/Q03kt3v40
The cover shows Comb Jelly (Mnemiopsis gardeni, Flagler Beach, FL) with oral end up and light refracting in a rainbow pattern off the comb rows. Size: ~2 cm long. Comb Jellies are a sister lineage to all other animals.
From Timothy Jegla’s lab (https://hubs.la/Q03kt3w-0).

John Wood (UCL) and colleagues review the development of analgesic drugs targeting sodium channels NaV1.7 and NaV1.8. FD...
04/28/2025

John Wood (UCL) and colleagues review the development of analgesic drugs targeting sodium channels NaV1.7 and NaV1.8. FDA approval of the NaV1.8 antagonist suzetrigine presages an exciting new era in analgesic treatment. https://hubs.la/Q03k30L90

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